Long Noncoding RNAs and Positional Identity As a practicing dermatologist, I am fascinated by what makes human skin from different parts of the body different, a fact that guides the diagnosis and treatment of many skin diseases. Restoration of proper organ function often requires restoring homeostatic gene regulation. Inappropriate activation of genes can give rise to birth defects, premature aging, or cancer, among many other diseases. Thus, how one genome encodes thousands of patterns in space and time is of central importance to biology and medicine. In many organisms with continual turnover of cells, the genome faces the additional challenge of ensuring the faithful transmission of information throughout a lifetimeĀover decades in the case of humans. These different cell types must be correctly arranged in spatial patterns to make functioning tissues and organs. Intricate mechanisms govern the choice to make skin, heart, or brain cells. The same genetic blueprint gives rise to thousands of cell types that make up the human body. Vice Provost for Undergraduate Education.Office of Vice President for Business Affairs and Chief Financial Officer.Office of VP for University Human Resources.Stanford Woods Institute for the Environment.Stanford Institute for Economic Policy Research (SIEPR).Institute for Stem Cell Biology and Regenerative Medicine.Institute for Human-Centered Artificial Intelligence (HAI).Institute for Computational and Mathematical Engineering (ICME).Freeman Spogli Institute for International Studies.Stanford Doerr School of Sustainability.
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